Precise and extraordinarily flexible
TAL effectors are a widely used technology for precise and efficient gene editing in live cells. This genome editing technology is known to function in a variety of host systems, including bacteria, yeast, plants, insects, zebrafish, and mammals. We have recently secured rights to certain proprietary methods related to TALs, clarifying a path for you to move confidently forward and innovate.
Thermo Fisher Scientific offers GeneArt PerfectMatch TALs; TAL effector nucleases with a new design that removes the 5′ base constraint and therefore can be designed to target any desired sequence within the genome. We also offer GeneArt Precision TALs for site-specific delivery of activators, chromatin modifiers, genomic labels, and cross-linking molecules.
Video on TALEN technology
Watch this online tutorial, presented by Dr. Jon Chesnut, Research Fellow and R&D lead, to learn more about GeneArt Precision TALs technology.
Table 1. Available effector domains
An essential tool for monitoring the efficiency of your genome editing experiments
When using genome editing tools such as CRISPRs, TALs, or zinc finger nucleases to obtain targeted mutations, it is necessary to determine the efficiency with which these nucleases cleave the target sequence prior to continuing with labor-intensive and expensive experiments. The GeneArt Genomic Cleavage Detection Kit provides a simple, reliable, and rapid method to determine the nuclease cleavage efficiency at a given locus.