Electron Microscopy for Life Sciences & Drug Discovery

From volume electron microscopy to atomic resolution cryo-EM

Thermo Scientific electron microscopy solutions are designed to enhance structural characterization across the life sciences, from enabling scientific discoveries to expanding the range of therapeutic targets accessible with structure-based drug design. Whether you’re determining high-resolution protein structure with cryo-electron microscopy or visualizing 3D cellular ultrastructure with volume EM, we provide the service, expertise, and technical support needed to optimize your whole workflow from sample preparation to data collection and analysis.

Cryo-Electron Microscopy | Cryo EM

Transmission Electron Microscopy Techniques | Life Sciences

SEM Biology | Scanning Electron Microscopy Biology

Our latest advancements in electron microscopy

As the world leader in serving science, Thermo Fisher Scientific is continuously developing products that help you push the limits of life sciences research and drug discovery. Cryo-electron microscopy (cryo-EM) in particular is driving critical structural insights that support breakthroughs in drug discovery across a variety of targets, many of which were once considered intractable.

 

 

 

 

 

Electron microscopy in biological research and drug design

Structural biology

Study the 3D structure of biological macromolecules and reveal new insights into their function and interactions.

Rational drug design

Discover how cryo-EM is being used to unlock new targets and modalities with structure-based drug design.

Cell and tissue biology

Access multi-scale structural data, ranging from molecular-resolution views of proteins and complexes to nanometer-resolution, 3D volumes of whole cells and microorganisms.

Plant biology and crop research

Gain structural insights into plant development, plant-microbe interactions, viral infections in plants, as well as the nature of photosynthesis efficiency and crop yields. 

Pathology imaging

Crisp, high-contrast images for the accurate analysis of membranes, cellular organelles, and pathogens. Easy to use, automated workflows with reduced time to results.

Infectious disease research

Visualize viruses and pathogens at near-atomic resolution to obtain critical insights into their structures and mechanisms, aiding in the development of vaccines and therapeutics.

Electron microscopy techniques for biological samples

Single particle analysis

Enables structural characterization of proteins and biomolecular complexes.

Cryo-electron tomography

Delivers structural information on molecules and their spatial arrangements within a cell.

Volume electron microscopy

Reveals the 3D ultrastructure of cells, tissues, and organisms.

Electron microscopy workflow solutions

Cryo-EM sample preparation

High-quality protein preparation solutions for electron microscopy workflows.

Data acquisition software

Integrated software platforms for automating cryo-EM data collection and screening.

Data visualization and analysis

2D-5D software platform for visualization, processing, and analysis of microscopy images.

Getting started in Cryo-EM

EM Resource Center

For Research Use Only. Not for use in diagnostic procedures.