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Orbitrap Tribrid Mass Spectrometers

Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Thermo Scientific Orbitrap Tribrid mass spectrometers enable high throughput analyses of challenging samples. Built on revolutionary Thermo Scientific Tribrid architecture, they combine the best of quadrupole, Orbitrap, and linear ion trap mass analyzers.

 

Go beyond with accurate and precise quantitation of low-abundance peptides in complex matrices, characterization of structural isomers, from drug metabolites to intact proteins, resolution of isobaric species, and native protein complexes structure characterization.

Which Orbitrap Tribrid MS is right for you?

 

Orbitrap Ascend Tribrid MS

Orbitrap Eclipse Tribrid MS

Orbitrap IQ-X Tribrid MS

 

Ultimate experimental throughput, versatility, and ease-of-use in multiomics, structural biology, and biopharma applications.

Ideally suited for proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments.

 Reveal complex chemical structures for compound identification and structure elucidation of small molecules.

Applications

Multi-omics, TMT, intact/top-down proteomics, targeted quantification, structural biology, ligand binding, biotherapeutics, fusion proteins, and new modalities.

Multi-omics, TMT, intact top-down proteomics, targeted quantification, crosslinking, biotherapeutics.

Metabolomics, lipidomics, drug development Met ID, extractables and leachables, industrial environmental health and more.

Ease-of-use
  • Auto-ready calibration source
  • Scheduled remote calibration
  • One click button calibration
  • One click button calibration
  • Auto-ready calibration source
  • Scheduled remote calibration
  • One click button calibration

Orbitrap mass range (m/z)

40-6,000 (16,000 with Native MS)

40-6,000 (8,000 with HMR)

40-2,000

Advanced workflows

SQUAD, AcquireX, TMT and TMTpro (up to 32plex), TurboTMT, RTS/RTLS, APD, DIA-PTCR

SQUAD, AcquireX, TMT and TMTpro (up to 32plex), TurboTMT, RTS/RTLS, APD, DIA-PTCR

SQUAD, AcquireX, RTS/RTLS
Optional add-ons IC/ETD/PTCR/UVPD/Native MS

IC/ETD/PTCR/UVPD/HMR

IC/UVPD

Applications

Proteomics

Orbitrap Tribrid mass spectrometers are the ultimate tool for high accuracy quantitation and deep characterization. Explore individual proteoform-level functionality in complex biological systems.

Metabolomics and lipidomics

Get deeper analysis into the metabolome by combining discovery and targeted methods. Characterize small molecules and lipids with intelligent acquisitions & unique fragmentation options.

Structural biology

Determine biological functions with Orbitrap Tribrid MS, the complete package for characterization of protein-complexes. Handle experiments from peptides up to ligand binding with native complexes.

Biopharmaceuticals

Keep pace with biopharmaceutical advances, from fusion proteins to oligonucleotides to MetID. The diversity of needs lends to the versatility of the Orbitrap Tribrid MS.

System architecture that enables multiple applications

Orbitrap Tribrid mass spectrometer architecture enables experimental flexibility and high performance. With three mass analyzers, the Quadrupole, the Orbitrap, the duel linear ion traps, as well as the Orbitrap and ion trap, which provide two detectors, enable unique methodologies and parallelization within experiments.

Related products

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We’ve got a column for that!

Solve your chromatography challenges with our extensive portfolio of HPLC and UHPLC columns. Bringing you a 40-year legacy of innovation, Thermo Scientific (U)HPLC columns offer an unmatched variety of chemistries, from C18 phases, to innovative mixed-mode chemistries, to the broadest range of solid core columns on the market, and more.

Ion mobility

The Thermo Scientific FAIMS Pro Duo interface extends differential ion mobility capability to multiple Thermo Scientific next-generation mass spectrometers, overcoming sample complexity and matrix interferences delivering increased productivity and data quality.

Connect projects, people, and instruments on a global level

Designed to support your digital transformation journey, the Thermo Scientific Ardia Platform is a scalable software solution for modern, dynamic (often cloud-based) environments. It connects and organizes projects, people, and instruments, on a global level, with web-based access and secure centralized data storage, enabling scientists to collaborate more efficiently and gain new insights faster, helping them get closer to the truth.

Services

Scalable service and support plan options

Discover flexible solutions to meet your specific service and support needs, from plans for single instruments to one that is customized to your entire lab or enterprise.

Resources

Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer

Scale up your multiomics analyses with throughput, versatility and ease-of-use.

Orbitrap Ascend Structural Biology Tribrid Mass Spectrometer

Unlock the intricacies of complex molecular structures.

Orbitrap Ascend BioPharma Tribrid Mass Spectrometer

Set new standards in biotherapeutic characterization.

Orbitrap Eclipse Tribrid Mass Spectrometer

Go beyond today’s discoveries with power and versatility.

Orbitrap IQ-X Tribrid Mass Spectrometer

Designed for small-molecule analysis.

Orbitrap Ascend MS Year in Review

Scientific compendium covering multiomics, structural biology and biopharma applications.

The LC-MS are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

 

Our Products have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in inaccurate results and, more seriously, health and safety risks. They are designated for Research Use Only Applications.