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NanoDrop Microvolume Spectrophotometers and Fluorometers

Simple, rapid, accurate quantification and qualification of DNA, RNA, and protein

Thermo Scientific NanoDrop™ Microvolume Spectrophotometers quickly quantify nucleic acids and proteins, and they assess purity from just ~1–2 µL (no cuvettes needed). These instruments support workflows like RT-qPCR and routine QC. Core UV-Vis methods use A260 for DNA/RNA and A280/A205 (plus optional colorimetric assays like BCA/Bradford/Lowry/Pierce 660) for proteins, and the family is widely adopted in labs with “over 55,000” scientific citations.

 

The NanoDrop Ultra spectrophotometer and fluorometer offers fluorescence capabilities, while the NanoDrop Eight model allows for multi-sample measurement. Both incorporate Thermo Scientific Acclaro™ Sample Intelligence Technology to flag common contaminants, distinguish DNA vs RNA, and report corrected “true” concentrations. If you do not need Acclaro sample intelligence, then you may be interested in the Thermo Scientific NanoDrop Lite Plus Spectrophotometer, which delivers trusted NanoDrop microvolume UV-Vis measurements fast, accurately, and with minimal sample usage. This all in a compact, budget-friendly instrument that’s perfect for routine lab quality checks and teaching environments.  

 

The NanoDrop spectrophotometer models and their key benefits

  • NanoDrop Ultra: Best for advanced applications and highest confidence in single-sample measurements; can also perform fluorimetry measurements
  • NanoDrop Eight: High throughput—measures 8 samples at once
  • NanoDrop Lite Plus: Compact, easy option for routine measurements

Ensure optimal performance of NanoDrop Ultra

The NanoDrop Ultra FL-1 Fluorescence Verification Assay Kit is essential for verifying the fluorometer performance in NanoDrop Ultra FL and NanoDrop UltraC FL spectrophotometers. (superscript the C's)

NanoDrop Ultra Microvolume Spectrophotometer and Fluorometer capabilities

Introducing the NanoDrop Ultra Family

The new NanoDrop Ultra Spectrophotometer and Fluorometer family of instruments includes four models. Learn more about the addition of fluorescence and the flexability that our series of models provides.

Regulatory compliance support

Optional security tools for selected NanoDrop microvolume spectrophotometers help your lab stay compliant with federal data regulations.

Acclaro advanced sample intelligence

With full-spectrum analysis, Acclaro Sample Intelligence software uses advanced chemometric algorithms to identify and correct for contaminants and differentiate DNA from RNA.

Acclaro Pro Software

The Acclaro™ Pro Software enables highly accurate measurement of concentrated nucleic acids and proteins. Suitable for advanced biopharma applications including protein and antibody production, vaccine development, and oligonucleotide manufacturing in research and diagnostics.

Fluorescence detection

NanoDrop Ultra FL and NanoDrop UltraC FL instruments evaluate contaminated DNA/RNA samples using the sensitivity and specificity of fluorescence and the versatility of spectrophotometry, all in one instrument.

Streamlined Integration with NanoDrop Ultra

NanoDrop Ultra UV-Vis Microvolume Spectrophotometers and Fluorometers, are part of a complimentary series of Thermo Fisher instruments such as Qubit, Countess 3/3 FL, and Neon Nxt systems. Providing enhanced sample information before downstream applications.

For Research Use Only. Not for use in diagnostic procedures.