The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system.
IL8RA has also been designated CD181 (cluster of differentiation 181) and CXCR1. CXCR1 recognizes CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif.
Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
alpha; C-C; C-C-CKR-1; C-X-C chemokine receptor type 1; CD128; CD181; CDw128a; chemokine (C-X-C motif) receptor 1; CKR-1; CMKAR1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8 Receptor alpha; IL-8 receptor type 1; IL-8R A; IL-RA; IL8R1; IL8RA; IL8RBA; interleukin 8 receptor; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A
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