ERK-1 is a classical MAP kinase involved in intracellular signaling in response to extracellular stimulus. ERK-1 is activated by growth factors, hormones, and phorbol esters. ERKs are widely expressed in different cells, and are involved in control of cell proliferation, cell differentiation, and cytoskeletal regulation. ERK-1 is a serine/threonine kinase which phosphorylates cytoplasmic signaling molecules, cell surface receptors, transcription factors, and microtubule associated proteins upon activation by molecules upstream in the signal transduction pathway.
ERK-1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; Microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MNK1; p44-ERK1; p44-MAPK; P44MAPK; PRKM3
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