Fibronectin is a disulfide-bonded dimer of ~230-250 kD. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodelling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).
CIG; Cold insoluble globulin; Cold-insoluble globulin; Fibronectin; fibronectin 1; FN; FN1; LETS; migration-stimulating factor; MSF; Transformation sensitive protein
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