Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; FLARA3; HSPC068; Influenza virus NS1A-binding protein; kelch-like family member 39; Kelch-like protein 39; KLHL39; NCX downstream gene 1; ND1; NS-1; NS1-binding protein; NS1-BP; NS1BP