The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
D12S370; LT beta-R; LT-beta receptor; LT-BETA-R; Lymphotoxin-beta receptor; TNF receptor-related protein; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3; Tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3
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