The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.
glutamine rich protein H65; NF-AT5; NFAT-like protein 1; NFATL1; Nuclear Factor Activated T-Cells; Nuclear factor of activated T cells 5; Nuclear factor of activated T-cells 5; osmotic response element-binding protein; Rel domain-containing transcription factor NFAT5; T cell transcription factor NFAT5; T-cell transcription factor NFAT5; TonE-binding protein; Tonicity-responsive enhanc; tonicity-responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein