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The CCAAT-binding factor NF-Y is a heteromeric transcription factor that specifically binds to CCAAT sequences in many eukaryotic genes. NF-Y is made up of three subunits, NF-YA, NF-YB and NF-YC. All three components are necessary for DNA binding. In each NF-Y subunit, the segment needed for formation of the NF-Y-DNA complex is conserved from yeast to human. These conserved segments are homologous to the histone-fold motif of eukaryotic histones. The DNA binding domains of the NF-YB and NF-YC subunits have been suggested to interact through a protein-protein histone-fold "handshake" motif in a manner analogous to the histone proteins, H2B and H2A, respectively.
CAAT box DNA-binding protein subunit C; CAAT-box DNA-binding protein subunit C; CBFC; CBF-C; CCAAT binding factor of CBF-C/NFY-C; CCAAT binding factor subunit C; CCAAT transcription binding factor subunit gamma; CCAAT-binding transcription factor subunit C; DKFZp667G242; fb98f01; FLJ45775; H1TF2A; HAP5; histone H1 transcription factor large subunit 2A; HSM; NFYC; NF-YC; Nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma; nuclear transcription factor Y, gamma; nuclear transcription factor-Y gamma; transactivator HSM-1; transactivator HSM-1/2; transcription factor NF-Y, C subunit; wu:fb98f01; zgc:55514
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