This protein involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. It requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. It also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. It plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It involved in the transport of L-arginine in monocytes and reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
amino acid permease; cationic amino acid transporter; Cationic amino acid transporter, y+ system; LAT-2; LAT3; member 6; SLC7A6; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; solute carrier family 7 (cationic amino acid transporter; solute carrier family 7 (cationic amino acid transporter, y+ system), member 6; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; y+ system; y+ system); Y+L amino acid transporter 2; y+LAT-2; Y+LAT2