Antibodies that detect Filamin A alpha-2 can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. This Rabbit polyclonal antibody targets Filamin A alpha-2 in Rat, Mouse and Human samples, and has been validated in experiments with 1 publication and 6 images featured in our data gallery.
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The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; FLN-A; Non-muscle filamin
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