PA5-29598 targets Filamin A alpha 2 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29598 immunogen is recombinant fragment corresponding to a region within amino acids 1769 and 2098 of Human Filamin A alpha 2.
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The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: ABP-280; ABPX; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; CVD1; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD