Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Abp1; Actin-binding protein 1; cervical mucin-associated protein; Cervical SH3P7; CMAP; DBNL; dbnl {ECO:0000312; drebrin F; drebrin like; drebrin-F; drebrin-like; drebrin-like protein; EMBL:AAH72483.1}; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; mAbp1; PP5423; SH3 domain-containing protein 7; Sh3p7; src homology 3 domain-containing protein HIP-55
100 µL
100 µL
150 µL
100 µL
100 µL
100 µL
100 µL
100 µg
100 µL
100 µg
100 µL
100 µL
10 µL
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk to a specialist nowIf an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support