JLP Antibodies

Target Information

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

Synonyms

3110018C07Rik; 4733401I23Rik; 4831406C20Rik; AW552012; Cancer/testis antigen 89; c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; CT89; HLC4; HLC6; HLC-6; HSS; Human lung cancer oncogene 6 protein; Jip4; JIP-4; JLP; JNK interacting protein; JNK/SAPK-associated protein; JNK/SAPK-associated protein 2; JNK-associated leucine-zipper protein; JNK-interacting leucine zipper; JNK-interacting protein 4; Jsap2; JSAP2a; Kiaa0516; lung cancer oncogene 4; Mapk8ip4; Max-binding protein; mitogen-activated protein kinase 8-interacting protein 4; PHET; PIG6; proliferation-inducing gene 6; Proliferation-inducing protein 6; Protein highly expressed in testis; SPAG9; sperm associated antigen 9; sperm associated antigen 9 variant 5; sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1; syd1