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NeoBiotechnologies

HER-2/c-erbB-2/neu/CD340 Monoclonal Antibody (HRB2/258), CF® 488

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Product Details

2064-MSM2-CF488-100T

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

5 µL/10^6 cells
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

HRB2/258

Immunogen

Recombinant extracellular domain of human HER-2 protein

Conjugate

CF® 488 CF® 488 CF® 488

Excitation/Emission Max

488/515 nm

Form

Liquid

Concentration

100 µg/mL

Amount

50 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; metas; Metastatic lymph node gene 19 protein; MLN 19; NEU proto-oncogene; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: ERBB2; HER2; MLN19; NEU; NGL

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Entrez Gene ID: (Rat) 24337

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Function(s)
RNA polymerase I core binding glycoprotein binding DNA binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity protein binding ATP binding protein C-terminus binding growth factor binding protein phosphatase binding ubiquitin protein ligase binding identical protein binding protein heterodimerization activity Hsp90 protein binding transmembrane signal receptor
Process(es)
liver development positive regulation of protein phosphorylation transcription, DNA-templated signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway nervous system development central nervous system development peripheral nervous system development heart development skeletal muscle tissue development neuromuscular junction development motor neuron axon guidance positive regulation of cell proliferation glial cell differentiation phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation positive regulation of cell growth response to progesterone regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus wound healing regulation of cell proliferation response to drug myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade tongue development estrous cycle regulation of cell differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation mammary gland involution regulation of ERK1 and ERK2 cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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