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NeoBiotechnologies

HER-2/c-erbB-2/neu/CD340 Monoclonal Antibody (HRB2/258)

View all (294) Her-2 (ErbB2) antibodies

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Product Details

2064-MSM2-P1ABX

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

HRB2/258

Immunogen

Recombinant extracellular domain of human HER-2 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; neu oncogene; p185; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185 precursor; neu/erbB-2; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2-like; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu; HER2; HER2/neu; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626

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Entrez Gene ID: (Human) 2064, (Rat) 24337

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Function(s)
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity ubiquitin protein ligase binding macromolecular complex binding Hsp90 protein binding
Process(es)
liver development signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development skeletal muscle tissue development neuromuscular junction development female pregnancy motor neuron axon guidance cell proliferation positive regulation of cell proliferation response to xenobiotic stimulus glial cell differentiation positive regulation of gene expression Schwann cell development response to muscle activity peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth axon regeneration response to progesterone regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus response to vitamin D multicellular organismal response to stress positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling tongue development estrous cycle regulation of cell differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development animal organ development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of small GTPase mediated signal transduction positive regulation of protein kinase B signaling mammary gland involution regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway response to dexamethasone positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of membrane permeability positive regulation of neural precursor cell proliferation protein phosphorylation enzyme linked receptor protein signaling pathway ERBB2 signaling pathway regulation of angiogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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