Search
Proteintech
TREX1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
24876-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TREX1 Fusion Protein Ag18325 (1-369 aa encoded by BC023630)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGPGARRQG RIVQGRPEMC FCPPPTPLPP LRILTLGTHT PTPCSSPGSA AGTYPTMGSQ ALPPGPMQTL IFFDMEATGL PFSQPKVTEL CLLAVHRCAL ESPPTSQGPP PTVPPPPRVV DKLSLCVAPG KACSPAASEI TGLSTAVLAA HGRQCFDDNL ANLLLAFLRR QPQPWCLVAH NGDRYDFPLL QAELAMLGLT SALDGAFCVD SITALKALER ASSPSEHGPR KSYSLGSIYT RLYGQSPPDS HTAEGDVLAL LSICQWRPQA LLRWVDAHAR PFGTIRPMYG VTASARTKPR PSAVTTTAHL ATTRNTSPSL GESRGTKDLP PVKDPGALSR EGLLAPLGLL AILTLAVATL YGLSLATPGE (1-369 aa encoded by BC023630)
Target Information
Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; Three-prime repair exonuclease 1; TREX1; unnamed protein product
Gene Aliases: AGS1; CRV; DRN3; HERNS; RVCLS; TREX1
UniProt ID: (Human) Q9NSU2
Entrez Gene ID: (Human) 11277
magnesium ion binding
nucleic acid binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
nuclease activity
exonuclease activity
exodeoxyribonuclease activity
protein binding
3'-5'-exodeoxyribonuclease activity
DNA binding, bending
double-stranded DNA 3'-5' exodeoxyribonuclease activity
3'-5' exonuclease activity
hydrolase activity
MutLalpha complex binding
MutSalpha complex binding
adenyl deoxyribonucleotide binding
identical protein binding
protein homodimerization activity
metal ion binding
WW domain binding
DNA damage checkpoint
blood vessel development
kidney development
adaptive immune response
organ or tissue specific immune response
activation of immune response
macrophage activation involved in immune response
lymphoid progenitor cell differentiation
immune response in brain or nervous system
inflammatory response to antigenic stimulus
T cell antigen processing and presentation
regulation of immunoglobulin production
heart morphogenesis
heart process
atrial cardiac muscle tissue development
generation of precursor metabolites and energy
regulation of glycolytic process
DNA metabolic process
DNA replication
DNA repair
mismatch repair
DNA modification
DNA catabolic process
DNA recombination
inflammatory response
immune response
cellular response to DNA damage stimulus
determination of adult lifespan
response to UV
regulation of gene expression
regulation of fatty acid metabolic process
regulation of metabolic process
mitotic G1 DNA damage checkpoint
transposition, RNA-mediated
regulation of type I interferon production
regulation of tumor necrosis factor production
cellular response to oxidative stress
cellular response to reactive oxygen species
cellular response to UV
cellular response to interferon-beta
apoptotic cell clearance
regulation of cellular respiration
innate immune response
regulation of innate immune response
establishment of protein localization
negative regulation of innate immune response
regulation of lipid biosynthetic process
regulation of inflammatory response
protein stabilization
regulation of T cell activation
defense response to virus
type I interferon signaling pathway
negative regulation of type I interferon-mediated signaling pathway
regulation of protein complex stability
cellular response to type I interferon
cellular response to gamma radiation
cellular response to hydroxyurea
immune complex formation
cGAS/STING signaling pathway
negative regulation of cGAS/STING signaling pathway
DNA synthesis involved in UV-damage excision repair
regulation of lysosome organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support