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Invitrogen
Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor™ 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
352588
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C3C2
Immunogen
Synthetic peptide derived from the mouse Claudin-5 protein
Conjugate
Alexa Fluor™ 488
Alexa Fluor™ 488
Alexa Fluor™ 488
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 4mg/mL BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reactivity has been confirmed with rat, human and mouse Claudin-5 using rat lung, mouse kidney, mouse small intestine, mouse lung homogenates, human colon tissue, and CACO-2 human cell line. This antibody reacts specifically with the ~ 22-24 kDa endogenous Claudin-5 protein. Excitation/Peak Emission (nm): 495/519
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain endothelial cell clone 1 protein; CLDN5; lung-specific membrane protein; transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome; unnamed protein product
Gene Aliases: AWAL; BEC1; CPETRL1; MBEC1; TMDVCF; TMVCF
UniProt ID: (Human) O00501, (Mouse) O54942, (Rat) Q9JKD6
Entrez Gene ID: (Human) 7122, (Mouse) 12741, (Rat) 65131
outflow tract morphogenesis
cell-cell junction assembly
transforming growth factor beta receptor signaling pathway
learning
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
negative regulation of angiogenesis
negative regulation of cell migration
maintenance of blood-brain barrier
myelination
negative regulation of vascular permeability
response to ethanol
palate development
face morphogenesis
tight junction assembly
positive regulation of establishment of endothelial barrier
positive regulation of bicellular tight junction assembly
establishment of blood-retinal barrier
cell-cell adhesion
establishment of endothelial barrier
negative regulation of complement-dependent cytotoxicity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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