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Invitrogen
Claudin 5 Monoclonal Antibody (4C3C2)
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FIGURE: 1 / 5
Claudin 5 Antibody (35-2500) in IHC (P)
Immunohistochemistry analysis of Claudin 5 showing staining in the Membrane and Cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at roo... View More
Product Details
35-2500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Amphibian,
Bovine,
Chicken,
Cynomolgus monkey,
Dog,
Guinea pig,
Human,
Mouse,
Pig,
Rat,
Sheep,
Xenopus,
Zebrafish
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C3C2
Immunogen
Synthetic peptide derived from the mouse Claudin-5 protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain endothelial cell clone 1 protein; Claudin-5; CLDN5; Lung-specific membrane protein; TMDVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome; unnamed protein product
Gene Aliases: AI854493; AWAL; BEC1; CLDN5; CPETRL1; MBEC1; TMDVCF; TMVCF
UniProt ID: (Human) O00501, (Rat) Q9JKD6, (Mouse) O54942
Entrez Gene ID: (Human) 7122, (Rat) 65131, (Mouse) 12741
outflow tract morphogenesis
cell-cell junction assembly
cell adhesion
transforming growth factor beta receptor signaling pathway
learning
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
negative regulation of angiogenesis
negative regulation of cell migration
maintenance of blood-brain barrier
myelination
negative regulation of vascular permeability
response to ethanol
palate development
face morphogenesis
bicellular tight junction assembly
tight junction assembly
positive regulation of establishment of endothelial barrier
positive regulation of bicellular tight junction assembly
establishment of blood-retinal barrier
single organismal cell-cell adhesion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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