Search

  • Statut des commandes
  • Commande rapide
  • Promos

QED Bioscience

Phospho-GSK3-alpha (Ser21) Polyclonal Antibody

View all (29) GSK3 alpha antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-GSK3-alpha (Ser21) Polyclonal Antibody

Product Details

43007-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence that includes phosphorylation site of Serine 21 (T-S-S(p)-F-A) derived from human GSK3 alpha and conjugated to KLH.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

Dulbecco's PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A

View more View less

Gene Aliases: 2700086H06Rik; GSK3A

View more View less

UniProt ID: (Human) P49840, (Rat) P18265, (Mouse) Q2NL51

View more View less

Entrez Gene ID: (Human) 2931, (Rat) 50686, (Mouse) 606496

View more View less

Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity receptor binding protein binding ATP binding kinase activity transferase activity protein kinase A catalytic subunit binding tau protein binding tau-protein kinase activity protein serine kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis glycogen metabolic process nervous system development insulin receptor signaling pathway negative regulation of signal transduction positive regulation of autophagy positive regulation of gene expression negative regulation of UDP-glucose catabolic process regulation of neuron projection development Wnt signaling pathway cell migration viral protein processing cell differentiation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway negative regulation of TOR signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to insulin stimulus cellular response to interleukin-3 proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process negative regulation of glycogen biosynthetic process positive regulation of protein catabolic process positive regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import negative regulation of insulin receptor signaling pathway excitatory postsynaptic potential negative regulation of cell growth involved in cardiac muscle cell development regulation of microtubule cytoskeleton organization cellular response to lithium ion cellular response to glucocorticoid stimulus positive regulation of adrenergic receptor signaling pathway negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway autosome genomic imprinting beta-arrestin-dependent dopamine receptor signaling pathway positive regulation of substrate adhesion-dependent cell spreading positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitophagy cellular response to oxygen-containing compound positive regulation of beta-amyloid formation positive regulation of protein targeting to mitochondrion positive regulation of establishment of protein localization negative regulation of type B pancreatic cell development negative regulation of glycogen (starch) synthase activity regulation of gene expression by genetic imprinting protein phosphorylation signal transduction positive regulation of peptidyl-threonine phosphorylation positive regulation of cAMP biosynthetic process positive regulation of peptidyl-serine phosphorylation hypermethylation of CpG island negative regulation of transferase activity cellular response to organic cyclic compound positive regulation of glycogen (starch) synthase activity carbohydrate metabolic process phosphorylation regulation of mitophagy
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support