Search

  • Contáctenos
  • Orden Rápida

Invitrogen

MECP2 Polyclonal Antibody

View all (42) MECP2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
MECP2 Polyclonal Antibody

Product Details

49-1029

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ELISA (ELISA)

1:500-1:1,000
-

Immunoprecipitation (IP)

50-100 µg/mL
-

ChIP assay (ChIP)

5 µg/1x10^6 cells
-

RNA Immunoprecipitation (RIP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Raised against the C-term of human MECP2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Amount

50 µg

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.05% sodium azide, 0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533879

Target Information

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp686A24160; MeCp-2 protein; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Methyl-CpG-binding protein 2; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product

View more View less

Gene Aliases: AUTSX3; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT

View more View less

UniProt ID: (Human) P51608

View more View less

Entrez Gene ID: (Human) 4204

View more View less

Function(s)
nucleic acid binding DNA binding chromatin binding transcription corepressor activity RNA binding mRNA binding protein binding methyl-CpG binding double-stranded methylated DNA binding siRNA binding binding, bridging histone reader activity molecular condensate scaffold activity promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process regulation of transcription from RNA polymerase II promoter glutamine metabolic process cellular biogenic amine metabolic process Notch signaling pathway chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization glucocorticoid metabolic process cell proliferation associative learning adult locomotory behavior visual learning post-embryonic development gene expression regulation of gene expression negative regulation of gene expression glial cell proliferation dendrite development negative regulation of angiogenesis proprioception sensory perception of pain cerebellum development ventricular system development neuron differentiation neuron projection development heterochromatin assembly cardiolipin metabolic process multicellular organismal response to stress social behavior regulation of gene expression, epigenetic neuron maturation negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration hypermethylation of CpG island negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylcholine metabolic process regulation of synaptic plasticity cell development catecholamine secretion neuromuscular process controlling posture neuromuscular process negative regulation of developmental process negative regulation of smooth muscle cell differentiation response to other organism excitatory postsynaptic potential positive regulation of glial cell proliferation long-term synaptic potentiation genetic imprinting positive regulation of microtubule nucleation trans-synaptic signaling by BDNF regulation of multicellular organismal development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support