Antibodies that detect MECP2 can be used in several scientific applications, including Western Blot, ELISA, Immunoprecipitation, Immunohistochemistry (Paraffin) and Immunocytochemistry. These antibodies target MECP2 in Human, Mouse, Rat and Chicken samples. Our MECP2 polyclonal, monoclonal and recombinant polyclonal antibodies are developed in Rabbit, Mouse and Rat. Find the MECP2 antibody that fits your needs. Choose from 1 of 31 MECP2 antibodies, which have been validated in experiments with 26 publications and 81 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
DKFZp686A24160; MeCp-2 protein; methyl CpG binding protein 2; Methyl-CpG-binding protein 2; testis tissue sperm-binding protein Li 41a
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