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Proteintech
MECP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10861-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MECP2 Fusion Protein Ag1309 (138-487 aa encoded by BC011612)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody reacts with the MECP2 and phosphorylated MECP2 proteins. The calculated molecular weight of MECP2 is 52 kDa, but the post-modified MECP2 protein is about 75-80 kDa.
Immunogen sequence: LIAYFEKVG DTSLDPNDFD FTVTGRGSPS RREQKPPKKP KSPKAPGTGR GRGRPKGSGT TRPKAATSEG VQVKRVLEKS PGKLLVKMPF QTSPGGKAEG GGATTSTQVM VIKRPGRKRK AEADPQAIPK KRGRKPGSVV AAAAAEAKKK AVKESSIRSV QETVLPIKKR KTRETVSIEV KEVVKPLLVS TLGEKSGKGL KTCKSPGRKS KESSPKGRSS SASSPPKKEH HHHHHHSESP KAPVPLLPPL PPPPPEPESS EDPTSPPEPQ DLSSSVCKEE KMPRGGSLES DGCPKEPAKT QPAVATAATA AEKYKHRGEG ERKDIVSSSM PRPNREEPVD SRTPVTERVS (138-487 aa encoded by BC011612)
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686A24160; MeCP-2; meCP-2 protein; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product
Gene Aliases: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2_e1; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10
UniProt ID: (Human) P51608, (Rat) Q00566, (Mouse) Q9Z2D6
Entrez Gene ID: (Human) 4204, (Rat) 29386, (Mouse) 17257
nucleic acid binding
DNA binding
chromatin binding
transcription corepressor activity
RNA binding
mRNA binding
protein binding
methyl-CpG binding
double-stranded methylated DNA binding
siRNA binding
binding, bridging
histone reader activity
molecular condensate scaffold activity
promoter-specific chromatin binding
four-way junction DNA binding
enzyme binding
protein domain specific binding
chromatin DNA binding
identical protein binding
histone deacetylase binding
unmethylated CpG binding
negative regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
associative learning
gene expression
negative regulation of gene expression
negative regulation of angiogenesis
neuron differentiation
regulation of gene expression, epigenetic
negative regulation of blood vessel endothelial cell migration
hypermethylation of CpG island
negative regulation of transcription, DNA-templated
cell development
negative regulation of developmental process
negative regulation of smooth muscle cell differentiation
regulation of multicellular organismal process
genetic imprinting
positive regulation of microtubule nucleation
axo-dendritic protein transport
protein localization to presynapse
behavioral fear response
response to hypoxia
startle response
neurological system process involved in regulation of systemic arterial blood pressure
regulation of respiratory gaseous exchange by neurological system process
ventricular cardiac muscle tissue development
inositol metabolic process
regulation of transcription from RNA polymerase II promoter
glutamine metabolic process
cellular biogenic amine metabolic process
triglyceride metabolic process
chemical synaptic transmission
synapse assembly
brain development
respiratory gaseous exchange
learning
memory
long-term memory
protein localization
glucocorticoid metabolic process
positive regulation of cell proliferation
adult locomotory behavior
visual learning
post-embryonic development
response to ionizing radiation
response to lead ion
regulation of gene expression
positive regulation of gene expression
oligodendrocyte development
dendrite development
proprioception
sensory perception of pain
spinal cord development
cerebellum development
ventricular system development
principal sensory nucleus of trigeminal nerve development
striatum development
hippocampus development
olfactory bulb development
thalamus development
cerebral cortex development
neuron projection development
heterochromatin assembly
positive regulation of synaptic plasticity
cardiolipin metabolic process
response to estradiol
multicellular organismal response to stress
social behavior
cellular response to potassium ion
response to cocaine
neuron maturation
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
phosphatidylcholine metabolic process
regulation of synaptic plasticity
lung alveolus development
oligodendrocyte differentiation
negative regulation of astrocyte differentiation
regulation of synapse organization
neuromuscular process controlling posture
neuromuscular process
sensory perception of touch
response to other organism
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of dendritic spine development
negative regulation of dendritic spine development
cellular response to isoquinoline alkaloid
negative regulation of locomotion involved in locomotory behavior
response to alcohol
regulation of action potential firing threshold
positive regulation of anterograde dense core granule transport
positive regulation of retrograde dense core granule transport
negative regulation of dendrite extension
positive regulation of dendrite extension
response to bisphenol A
negative regulation of respiratory gaseous exchange
positive regulation of branching morphogenesis of a nerve
negative regulation of primary miRNA processing
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