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Proteintech
TDP-43 Monoclonal Antibody (6H6E12)
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Product Details
60019-2-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Yeast
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6H6E12
Immunogen
TDP-43 (human specific) Fusion Protein Ag1231
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Amount
160.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
60019-2-Ig is a mouse monoclonal antibody recognizing the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues. Notably this antibody only recognizes human TDP-43 but not reacts with mouse or rat TDP-43.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OTTHUMP00000002171; OTTHUMP00000002173; RP4-635E18.2; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TARDBP; TDP-43; unnamed protein product
Gene Aliases: ALS10; TARDBP; TDP-43; TDP43
UniProt ID: (Human) Q13148
Entrez Gene ID: (Human) 23435
negative regulation of protein phosphorylation
mRNA processing
RNA splicing
gene expression
regulation of gene expression
negative regulation of gene expression
regulation of protein stability
positive regulation of insulin secretion
response to endoplasmic reticulum stress
positive regulation of protein import into nucleus
regulation of circadian rhythm
regulation of apoptotic process
negative regulation by host of viral transcription
rhythmic process
regulation of cell cycle
3'-UTR-mediated mRNA destabilization
3'-UTR-mediated mRNA stabilization
nuclear inner membrane organization
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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