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Proteintech
ITM2C Monoclonal Antibody (2E8G11)
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Product Details
60095-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E8G11
Immunogen
ITM2C Fusion Protein Ag4409 (1-230 aa encoded by BC025742)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Amount
142.5 µg
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVKISFQPA VAGIKGDKAD KASASAPAPA SATEILLTPA REEQPPQHRS KRGSSVGGVC YLSMGMVVLL MGLVFASVYI YRYFFLAQLA RDNFFRCGVL YEDSLSSQVR TQMELEEDVK IYLDENYERI NVPVPQFGGG DPADIIHDFQ RRGTYLPQTY IIQEEMVVTE HVSDKEALGS FIYHLCNGKD TYRLRRRATR RRINKRGAKN CNAIRHFENT FVVETLICGV V (1-230 aa encoded by BC025742)
Target Information
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; ITM2C; similar to E25C and BRI; Transmembrane protein BRI3; unnamed protein product
Gene Aliases: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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