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Proteintech
ST2 Monoclonal Antibody (7A2A7)
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Product Details
60112-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7A2A7
Immunogen
ST2 Fusion Protein Ag2555 (4-328 aa encoded by BC030975)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WILAILTIL MYSTAAKFSK QSWGLENEAL IVRCPRQGKP SYTVDWYYSQ TNKSIPTQER NRVFASGQLL KFLPAAVADS GIYTCIVRSP TFNRTGYANV TIYKKQSDCN VPDYLMYSTV SGSEKNSKIY CPTIDLYNWT APLEWFKNCQ ALQGSRYRAH KSFLVIDNVM TEDAGDYTCK FIHNENGANY SVTATRSFTV KDEQGFSLFP VIGAPAQNEI KEVEIGKNAN LTCSACFGKG TQFLAAVLWQ LNGTKITDFG EPRIQQEEGQ NQSFSNGLAC LDMVLRIADV KEEDLLLQYD CLALNLHGLR RHTVRLSRKN PSKECF (4-328 aa encoded by B C030975)
Target Information
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL-1RL1; IL-33R; interleukin 1 receptor-related protein; Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Interleukin1 receptor like 1; Lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; soluble protein receptor; unnamed protein product
Gene Aliases: DER4; FIT-1; FIT1; IL1RL1; IL33R; Ly84; ST2; St2-rs1; ST2L; ST2V; Ste2; T1; T1/ST2
UniProt ID: (Human) Q01638, (Mouse) P14719, (Rat) Q62611
Entrez Gene ID: (Human) 9173, (Pig) 100127134, (Mouse) 17082, (Rat) 25556
negative regulation of T-helper 1 type immune response
inflammatory response
immune response
signal transduction
response to wounding
macrophage differentiation
negative regulation of interferon-gamma production
positive regulation of chemokine production
positive regulation of interleukin-5 production
interleukin-33-mediated signaling pathway
positive regulation of macrophage activation
positive regulation of inflammatory response
negative regulation of cell proliferation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of chemokine secretion
cytokine-mediated signaling pathway
cellular response to peptide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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