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Proteintech
Cytokeratin 19 Monoclonal Antibody (3G1E4)
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Product Details
60187-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3G1E4
Immunogen
Cytokeratin 19 Fusion Protein Ag7407 (1-400 aa encoded by BC002539)
Conjugate
Form
Liquid
Concentration
1.13 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody, generated against full length KRT19 protein, also recognizes KRT17, another type I keratin homologous to KRT19. KRT17 is used as a marker for trauma.
Immunogen sequence: MTSYSYRQS SATSSFGGLG GGSVRFGPGV AFRAPSIHGG SGGRGVSVSS ARFVSSSSSG GYGGGYGGVL TASDGLLAGN EKLTMQNLND RLASYLDKVR ALEAANGELE VKIRDWYQKQ GPGPSRDYSH YYTTIQDLRD KILGATIENS RIVLQIDNAR LAADDFRTKF ETEQALRMSV EADINGLRRV LDELTLARTD LEMQIEGLKE ELAYLKKNHE EEISTLRGQV GGQVSVEVDS APGTDLAKIL SDMRSQYEVM AEQNRKDAEA WFTSRTEELN REVAGHTEQL QMSRSEVTDL RRTLQGLEIE LQSQLSMKAA LEDTLAETEA RFGAQLAHIQ ALISGIEAQL GDVRADSERQ NQEYQRLMDI KSRLEQEIAT YRSLLEGQED HYNNLSASKV L (1-400 aa encoded by BC002539)
Target Information
Cytokeratin 19 is part of a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight from 40-68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. For example, cytokeratin 19 is not expressed in hepatocytes, therefore, it is useful in the identification of liver metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40-kDa keratin intermediate filament; C K1CS; CK 19; CK-19; cytokeratin 19; Cytokeratin-19; K19; keratin 19, type I; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin-19; MGC15366; unnamed protein product
Gene Aliases: CK19; K19; K1CS; KRT19
UniProt ID: (Human) P08727
Entrez Gene ID: (Human) 3880
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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