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Proteintech
CD40L/CD154 Monoclonal Antibody (MR1)
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FIGURE: 1 / 1
CD40L/CD154 Antibody (65129-1-IG100UG) in Flow
1x10^6 unstimulated or PMA and ionomycin stimulated (overnight) BALB/c mouse CD4+ T cells were surface co-stained with CoraLite® Plus 647 Anti-Mouse CD4 (GK1.5) and 0.25 µg Anti-Mouse CD154 (65129-1-Ig, Clone: MR1) and FITC anti-Armenian Hamster IgG at dilution 1:100. Cells were not fixed.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
65129-1-IG100UG
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Armenian hamster
/ IgG
Class
Monoclonal
Type
Antibody
Clone
MR1
Immunogen
fusion protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H-CD-40-L; M-CD-40-L; membrane protein; RP23-153G22.3; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5
Gene Aliases: CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP
UniProt ID: (Mouse) P27548
Entrez Gene ID: (Mouse) 21947
regulation of immunoglobulin production
regulation of immune system process
positive regulation of immune response to tumor cell
inflammatory response
immune response
signal transduction
cell surface receptor signaling pathway
integrin-mediated signaling pathway
regulation of gene expression
positive regulation of gene expression
CD40 signaling pathway
platelet activation
B cell differentiation
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
isotype switching
positive regulation of MHC class II biosynthetic process
dendritic cell differentiation
positive regulation of endothelial cell apoptotic process
positive regulation of dendritic cell differentiation
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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