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Proteintech
SMARCA4 Monoclonal Antibody (2E6B6)
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Product Details
66561-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2E6B6
Immunogen
SMARCA4 Fusion Protein Ag16256 (207-298 aa encoded by BC150298)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRPMPGMQQ QMPTLPPPSV SATGPGPGPG PGPGPGPGPA PPNYSRPHGM GGPNMPPPGP SGVPPGMPGQ PPGGPPKPWP EGPMANAAAP TST (207-298 aa encoded by BC150298)
Target Information
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1; unnamed protein product
Gene Aliases: BAF190; BAF190A; brg-1; BRG1; CSS4; hSNF2b; MRD16; OTSC12; RTPS2; SMARCA4; SNF2; SNF2-beta; SNF2B; SNF2L4; SNF2LB; SWI2
UniProt ID: (Human) P51532
Entrez Gene ID: (Human) 6597, (Rat) 171379
RNA polymerase I CORE element sequence-specific DNA binding
transcription cofactor binding
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
RNA binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
Tat protein binding
nucleosomal DNA binding
histone binding
identical protein binding
androgen receptor binding
DNA polymerase binding
ATP-dependent chromatin remodeler activity
nucleosome array spacer activity
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
transcription factor binding
protein complex binding
protein N-terminus binding
lysine-acetylated histone binding
DNA helicase
negative regulation of transcription from RNA polymerase II promoter
RNA polymerase I preinitiation complex assembly
neural retina development
chromatin organization
nucleosome disassembly
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
regulation of mitotic metaphase/anaphase transition
positive regulation of Wnt signaling pathway
negative regulation of cell growth
heterochromatin assembly
positive regulation by host of viral transcription
positive regulation of T cell differentiation
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of androgen receptor signaling pathway
regulation of G0 to G1 transition
positive regulation of cold-induced thermogenesis
positive regulation of signal transduction by p53 class mediator
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of stem cell population maintenance
positive regulation of glucose mediated signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
methylation-dependent chromatin silencing
transcription, DNA-templated
spermatid development
glial cell fate determination
heart development
DNA methylation on cytosine within a CG sequence
stem cell population maintenance
neurogenesis
extracellular matrix organization
keratinocyte differentiation
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
positive regulation of DNA binding
histone H3 acetylation
embryonic organ morphogenesis
epidermis morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
definitive erythrocyte differentiation
heart trabecula formation
pharyngeal arch artery morphogenesis
lens fiber cell development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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