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Proteintech

SMARCA4 Monoclonal Antibody (2E6B6), CoraLite® 594

View all (35) BRG1 antibodies

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Product Details

CL594-66561

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2E6B6

Immunogen

Recombinant Protein

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1; unnamed protein product

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Gene Aliases: BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; OTSC12; RTPS2; SMARCA4; SNF2; SNF2-beta; SNF2B; SNF2L4; SNF2LB; SWI2

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UniProt ID: (Human) P51532

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Entrez Gene ID: (Human) 6597

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Function(s)
RNA polymerase I CORE element sequence-specific DNA binding transcription cofactor binding p53 binding DNA binding chromatin binding transcription coactivator activity transcription corepressor activity RNA binding helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity Tat protein binding nucleosomal DNA binding histone binding identical protein binding androgen receptor binding DNA polymerase binding ATP-dependent chromatin remodeler activity nucleosome array spacer activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter RNA polymerase I preinitiation complex assembly neural retina development chromatin organization nucleosome disassembly chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development positive regulation of cell proliferation regulation of mitotic metaphase/anaphase transition positive regulation of Wnt signaling pathway negative regulation of cell growth heterochromatin assembly positive regulation by host of viral transcription positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of androgen receptor signaling pathway regulation of G0 to G1 transition positive regulation of cold-induced thermogenesis positive regulation of signal transduction by p53 class mediator positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of stem cell population maintenance positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of G1/S transition of mitotic cell cycle positive regulation of double-strand break repair regulation of nucleotide-excision repair
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