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Proteintech

NEUROD1 Monoclonal Antibody (3E10F1)

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NEUROD1 Monoclonal Antibody (3E10F1)

Product Details

66691-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3E10F1

Immunogen

NEUROD1 Fusion Protein Ag27606 (1-356 aa encoded by BC009046)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

150 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTKSYSESG LMGEPQPQGP PSWTDECLSS QDEEHEADKK EDDLEAMNAE EDSLRNGGEE EDEDEDLEEE EEEEEEDDDQ KPKRRGPKKK KMTKARLERF KLRRMKANAR ERNRMHGLNA ALDNLRKVVP CYSKTQKLSK IETLRLAKNY IWALSEILRS GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ NQDMPPHLPT ASASFPVHPY SYQSPGLPSP PYGTMDSSHV FHVKPPPHAY SAALEPFFES PLTDCTSPSF DGPLSPPLSI NGNFSFKHEP SAEFEKNYAF TMHYPAATLA GAQSHGSIFS GTAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD (1-356 aa encoded by BC009046)

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; Beta-cell E-box transcriptional activator 2; Beta2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; NeuroD1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; unnamed protein product

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Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1; T2D

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UniProt ID: (Human) Q13562, (Mouse) Q60867

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Entrez Gene ID: (Human) 4760, (Mouse) 18012

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding protein heterodimerization activity protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity double-stranded DNA binding transcription coactivator activity transcription factor binding basic helix-loop-helix transcription factor
Process(es)
pancreatic A cell fate commitment pancreatic PP cell fate commitment regulation of transcription, DNA-templated transcription from RNA polymerase II promoter JAK-STAT cascade nervous system development sensory organ development response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion cell differentiation hindbrain development endocrine pancreas development positive regulation of insulin secretion amacrine cell differentiation enteroendocrine cell differentiation glucose homeostasis camera-type eye development positive regulation of apoptotic process cell fate commitment positive regulation of cell differentiation regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance axon development cellular response to glucocorticoid stimulus negative regulation of type B pancreatic cell apoptotic process transcription, DNA-templated nucleocytoplasmic transport nitric oxide mediated signal transduction multicellular organism development regulation of cell cycle arrest cellular response to glucose stimulus positive regulation of transcription regulatory region DNA binding
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