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Proteintech

NEUROD1 Monoclonal Antibody (3E10F1), CoraLite® 488

View all (25) NeuroD1 antibodies

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Product Details

CL48866691100UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3E10F1

Conjugate

CoraLite® 488 CoraLite® 488 CoraLite® 488

Excitation/Emission Max

490/515 nm

Form

Liquid

Concentration

1.7 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; unnamed protein product

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Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1; T2D

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UniProt ID: (Human) Q13562

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Entrez Gene ID: (Human) 4760

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding protein heterodimerization activity protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding sequence-specific double-stranded DNA binding
Process(es)
pancreatic A cell fate commitment pancreatic PP cell fate commitment regulation of transcription, DNA-templated transcription from RNA polymerase II promoter JAK-STAT cascade nervous system development sensory organ development response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion cell differentiation hindbrain development endocrine pancreas development positive regulation of insulin secretion amacrine cell differentiation enteroendocrine cell differentiation glucose homeostasis camera-type eye development positive regulation of apoptotic process cell fate commitment positive regulation of cell differentiation regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance axon development cellular response to glucocorticoid stimulus negative regulation of type B pancreatic cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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