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Proteintech
NEUROD1 Monoclonal Antibody (3E10F1), CoraLite® 488
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FIGURE: 1 / 1
NEUROD1 Antibody (CL48866691100UL) in Flow
1X10^6 SH-SY5Y cells were intracellularly stained with 0.4 µg CoraLite 488 Anti-Human NEUROD1 (Product # CL48866691100UL), Clone:3E10F1) (red), or 0.4 µg Mouse IgG1 Isotype Control (CL488-66360, Clone: T1F8D3F10) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL48866691100UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E10F1
Conjugate
Excitation/Emission Max
490/515 nm
Form
Liquid
Concentration
1.7 mg/mL
Amount
170 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; unnamed protein product
Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1; T2D
UniProt ID: (Human) Q13562
Entrez Gene ID: (Human) 4760
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
sequence-specific double-stranded DNA binding
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
JAK-STAT cascade
nervous system development
sensory organ development
response to glucose
anterior/posterior pattern specification
dentate gyrus development
cerebellum development
neurogenesis
signal transduction involved in regulation of gene expression
insulin secretion
cell differentiation
hindbrain development
endocrine pancreas development
positive regulation of insulin secretion
amacrine cell differentiation
enteroendocrine cell differentiation
glucose homeostasis
camera-type eye development
positive regulation of apoptotic process
cell fate commitment
positive regulation of cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
embryonic organ morphogenesis
inner ear development
regulation of insulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of intestinal epithelial structure maintenance
axon development
cellular response to glucocorticoid stimulus
negative regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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