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Proteintech
CRACR2A Monoclonal Antibody (4C1F5)
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Product Details
66787-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C1F5
Immunogen
CRACR2A Fusion Protein Ag7525 (1-395 aa encoded by BC004524)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes both of CRACR2A-c and CRACR2A-a.
Immunogen sequence: MAAPDGRVV SRPQRLGQGS GQGPKGSGAC LHPLDSLEQK ETQEQTSGQL VMLRKAQEFF QTCDAEGKGF IARKDMQRLH KELPLSLEEL EDVFDALDAD GNGYLTPQEF TTGFSHFFFS QNNPSQEDAG EQVAQRHEEK VYLSRGDEDL GDMGEDEEAQ FRMLMDRLGA QKVLEDESDV KQLWLQLKKE EPHLLSNFED FLTRIISQLQ EAHEEKNELE CALKRKIAAY DEEIQHLYEE MEQQIKSEKE QFLLKDTERF QARSQELEQK LLCKEQELEQ LTQKQKRLEG QCTALHHDKH ETKAENTKLK LTNQELAREL ERTSWELQDA QQQLESLQQE ACKLHQEKEM EVYRVTESLQ REKAGLLKQL DFLRCVGGHW PVLRAPPRSL GSEGPV (1-395 aa encoded by B C004524)
Target Information
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; Calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Ras-related protein Rab-46; unnamed protein product
Gene Aliases: CRACR2A; EFCAB4B; RAB46
UniProt ID: (Human) Q9BSW2
Entrez Gene ID: (Human) 84766
store-operated calcium entry
adaptive immune response
immune system process
ion transport
calcium ion transport
protein localization
vesicle-mediated transport
endosomal transport
activation of store-operated calcium channel activity
response to histamine
T-helper 1 cell differentiation
positive regulation of JNK cascade
positive regulation of calcium ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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