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Proteintech
CRACR2A Monoclonal Antibody (4C1F5), CoraLite® Plus 488
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Product Details
CL48866787100UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C1F5
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; Calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Ras-related protein Rab-46; unnamed protein product
Gene Aliases: CRACR2A; EFCAB4B; RAB46
UniProt ID: (Human) Q9BSW2
Entrez Gene ID: (Human) 84766
store-operated calcium entry
adaptive immune response
immune system process
ion transport
calcium ion transport
protein localization
vesicle-mediated transport
endosomal transport
activation of store-operated calcium channel activity
response to histamine
T-helper 1 cell differentiation
positive regulation of JNK cascade
positive regulation of calcium ion transport
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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