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Proteintech
ESRRB Monoclonal Antibody (3E10C1)
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Product Details
66818-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E10C1
Immunogen
ESRRB Fusion Protein Ag18626 (1-91 aa encoded by BC131517)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSDDRHLG SSCGSFIKTE PSSPSSGIDA LSHHSPSGSS DASGGFGLAL GTHANGLDSP PMFAGAGLGG TPCRKSYEDC ASGIMEDSAI KC (1-91 aa encoded by BC131517)
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ERR beta-2; ERR-beta; ERRbeta; estrogen receptor related 2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; estrogen-related receptor, beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2; unnamed protein product
Gene Aliases: DFNB35; ERR beta-2; Err-2; ERR2; ERRb; ERRB2; ERRbeta2; ESRL2; ESRRB; Estrrb; NR3B2
UniProt ID: (Human) O95718, (Mouse) Q61539, (Rat) P11475
Entrez Gene ID: (Human) 2103, (Mouse) 26380, (Rat) 299210
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
RNA polymerase II core binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
zinc ion binding
estrogen response element binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription coactivator activity
transcription factor binding
embryonic placenta development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell proliferation
stem cell division
stem cell population maintenance
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
somatic stem cell population maintenance
cell dedifferentiation
photoreceptor cell maintenance
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
inner ear development
morula formation
positive regulation of stem cell population maintenance
regulation of stem cell division
negative regulation of stem cell differentiation
in utero embryonic development
trophectodermal cellular morphogenesis
trophectodermal cell proliferation
transcription, DNA-templated
steroid hormone mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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