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Proteintech
Alpha Actinin Monoclonal Antibody (1E2E1)
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Product Details
66895-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E2E1
Immunogen
a-Actinin Fusion Protein Ag28383
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actinin 1 smooth muscle; alpha actinin 1a; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; epididymis secretory sperm binding protein; F-actin cross-linking protein; FLJ40884; FLJ54432; non-muscle alpha-actinin 1; Non-muscle alpha-actinin-1; unnamed protein product
Gene Aliases: 3110023F10Rik; ACTN1; Actn1a; BDPLT15
UniProt ID: (Human) P12814, (Rat) Q9Z1P2, (Mouse) Q7TPR4
Entrez Gene ID: (Human) 87, (Rat) 81634, (Mouse) 109711
transcription coactivator activity
double-stranded RNA binding
actin binding
integrin binding
calcium ion binding
protein binding
cytoskeletal protein binding
vinculin binding
identical protein binding
protein homodimerization activity
ion channel binding
metal ion binding
actin filament binding
structural constituent of postsynapse
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
focal adhesion assembly
actin filament bundle assembly
negative regulation of cellular component movement
actin crosslink formation
regulation of nucleic acid-templated transcription
cortical cytoskeleton organization
actin filament organization
actin cytoskeleton organization
platelet activation
platelet formation
platelet morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
anatomical structure formation involved in morphogenesis
actin filament network formation
muscle cell development
platelet aggregation
postsynapse organization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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