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SIN3A Monoclonal Antibody (2B12E8)

View all (17) SIN3A antibodies

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Product Details

67197-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2B12E8

Immunogen

SIN3A Fusion Protein Ag28865

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Amount

150 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Mammalian Sin3 (mSin3) is a 150 kDa protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin3A and mSin3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Histone deacetylase complex subunit Sin3a; Mammalian Sin3A; Paired amphipathic helix protein Sin3a; similar to yeast SIN3; SIN; SIN3 homolog A, transcription regulator; SIN3 transcription regulator homolog A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A; transcriptional regulator, SIN3A; unnamed protein product

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Gene Aliases: AW553200; CHR15DELq24; DEL15Q24; Kiaa4126; mKIAA4126; mSin3A; Sin3; SIN3A; WITKOS

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UniProt ID: (Human) Q96ST3, (Mouse) Q60520

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Entrez Gene ID: (Human) 25942, (Rat) 363067, (Mouse) 20466

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Function(s)
DNA binding chromatin binding transcription corepressor activity RNA binding protein binding macromolecular complex binding RNA polymerase II sequence-specific DNA binding transcription factor binding transcription regulator inhibitor activity transcription regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding histone deacetylase activity transcription factor binding protein complex binding protein deacetylase activity chromatin/chromatin-binding, or -regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development activation of innate immune response positive regulation of defense response to virus by host hematopoietic progenitor cell differentiation DNA replication regulation of transcription, DNA-templated protein localization regulation of hormone levels positive regulation of G2/M transition of mitotic cell cycle cerebral cortex neuron differentiation negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of axon extension heterochromatin assembly negative regulation of circadian rhythm negative regulation of apoptotic process positive regulation of neuron differentiation negative regulation of transcription, DNA-templated rhythmic process response to methylglyoxal type I interferon signaling pathway cellular response to glucose stimulus cellular response to tert-butyl hydroperoxide negative regulation of protein localization to nucleus negative regulation of stem cell population maintenance positive regulation of stem cell population maintenance cellular response to dopamine transcription from RNA polymerase II promoter protein deacetylation aging response to organonitrogen compound histone deacetylation positive regulation of chromatin silencing cellular protein localization regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of transcription from RNA polymerase II promoter negative regulation of histone H3-K27 acetylation negative regulation of transcription regulatory region DNA binding transcription, DNA-templated
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