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SIN3A Monoclonal Antibody (2B12E8), CoraLite® Plus 488
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FIGURE: 1 / 1
SIN3A Antibody (CL488-67197) in Flow
1X10^6 A431 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human SIN3A (CL488-67197, Clone:2B12E8) (red), or 0.4 µg Control Antibody. Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67197
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B12E8
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVTP SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ SHAHPAPPVA PVQGQQQFQR LKVVFSSFSW VKKFIFSRKY WLQLVGCGGT TSNLRY
Target Information
Mammalian Sin3 (mSin3) is a 150 kDa protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin3A and mSin3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone deacetylase complex subunit Sin3a; Mammalian Sin3A; Paired amphipathic helix protein Sin3a; similar to yeast SIN3; SIN; SIN3 homolog A, transcription regulator; SIN3 transcription regulator homolog A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A; transcriptional regulator, SIN3A; unnamed protein product
Gene Aliases: AW553200; CHR15DELq24; DEL15Q24; Kiaa4126; mKIAA4126; mSin3A; Sin3; SIN3A; WITKOS
UniProt ID: (Human) Q96ST3, (Mouse) Q60520
Entrez Gene ID: (Human) 25942, (Rat) 363067, (Mouse) 20466
DNA binding
chromatin binding
transcription corepressor activity
RNA binding
protein binding
macromolecular complex binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
transcription regulatory region sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
transcription factor binding
protein complex binding
protein deacetylase activity
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
activation of innate immune response
positive regulation of defense response to virus by host
hematopoietic progenitor cell differentiation
DNA replication
regulation of transcription, DNA-templated
protein localization
regulation of hormone levels
positive regulation of G2/M transition of mitotic cell cycle
cerebral cortex neuron differentiation
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of axon extension
heterochromatin assembly
negative regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
rhythmic process
response to methylglyoxal
type I interferon signaling pathway
cellular response to glucose stimulus
cellular response to tert-butyl hydroperoxide
negative regulation of protein localization to nucleus
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
cellular response to dopamine
transcription from RNA polymerase II promoter
protein deacetylation
aging
response to organonitrogen compound
histone deacetylation
positive regulation of chromatin silencing
cellular protein localization
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K27 acetylation
negative regulation of transcription regulatory region DNA binding
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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