Search
Proteintech
TYK2 Monoclonal Antibody (1E1A10)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
67411-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E1A10
Immunogen
TYK2 Fusion Protein Ag9442
Conjugate
Form
Liquid
Concentration
800 µg/mL
Amount
120 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; unnamed protein product
Gene Aliases: IMD35; JTK1; TYK2
UniProt ID: (Human) P29597
Entrez Gene ID: (Human) 7297
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
immune response
JAK-STAT cascade
cell proliferation
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
type III interferon-mediated signaling pathway
positive regulation of T cell proliferation
regulation of JAK-STAT cascade
positive regulation of JAK-STAT cascade
regulation of alpha-beta T cell activation
positive regulation of NK T cell proliferation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
cellular response to virus
interleukin-10-mediated signaling pathway
positive regulation of protein localization to nucleus
positive regulation of T-helper 17 type immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support