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Proteintech
TYK2 Monoclonal Antibody (1E1A10), CoraLite® 594
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Product Details
CL594-67411
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E1A10
Immunogen
TYK2 fusion protein Ag9442
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RDLGEGHFG KVSLYCYDPT NDGTGEMVAV KALKADCGPQ HRSGWKQEID ILRTLYHEHI IKYKGCCEDQ GEKSLQLVME YVPLGSLRDY LPRHSIGLAQ LLLFAQQICE GMAYLHSQHY IHRDLAARNV LLDNDRLVKI GDFGLAKAVP EGHEYYRVRE DGDSPVFWYA PECLKEYKFY YASDVWSFGV TLYELLTHCD SSQSPPTKFL ELIGIAQGQM TVLRLTELLE RGERLPRPDK CPCEVYHLMK NCWETEASFR PTFENLIPIL KTVHEKYQGQ APSVFSVC
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; unnamed protein product
Gene Aliases: IMD35; JTK1; TYK2
UniProt ID: (Human) P29597
Entrez Gene ID: (Human) 7297
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
immune response
JAK-STAT cascade
cell proliferation
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
type III interferon-mediated signaling pathway
positive regulation of T cell proliferation
regulation of JAK-STAT cascade
positive regulation of JAK-STAT cascade
regulation of alpha-beta T cell activation
positive regulation of NK T cell proliferation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
cellular response to virus
interleukin-10-mediated signaling pathway
positive regulation of protein localization to nucleus
positive regulation of T-helper 17 type immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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