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Proteintech
WASF3 Monoclonal Antibody (3B7D10)
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Product Details
67620-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3B7D10
Immunogen
WASF3 fusion protein Ag29991
Conjugate
Form
Liquid
Concentration
500 µg/mL
Amount
75 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin polymerization protein; Actin-binding protein WASF3; Protein WAVE-3; unnamed protein product; Verprolin homology domain-containing protein 3; WAS protein family member 3; WAS protein family, member 3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; WASP-family protein; Wiskott-Aldrich syndrome protein family member 3
Gene Aliases: Brush-1; KIAA0900; SCAR3; WASF3; WAVE3
UniProt ID: (Human) Q9UPY6, (Mouse) Q8VHI6
Entrez Gene ID: (Pig) 100155782, (Human) 10810, (Rabbit) 100353601, (Mouse) 245880, (Rat) 682937
cytoskeleton organization
regulation of cell shape
oligodendrocyte development
lamellipodium assembly
actin cytoskeleton organization
actin filament polymerization
positive regulation of myelination
protein-containing complex assembly
modification of postsynaptic actin cytoskeleton
positive regulation of Arp2/3 complex-mediated actin nucleation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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