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Proteintech
Cardiac Troponin T Monoclonal Antibody (4E2D8)
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Product Details
68300-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4E2D8
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T form I; cardiac troponin T isoform I; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; TnTC; troponin T; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac; unnamed protein product
Gene Aliases: CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Chicken) P02642, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Human) 7139, (Rabbit) 100009428, (Pig) 100622450, (Chicken) 396433, (Rat) 24837, (Mouse) 21956
regulation of muscle contraction
striated muscle contraction
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
sarcomere organization
response to calcium ion
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
heart development
metabolic process
regulation of muscle filament sliding speed
protein heterooligomerization
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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