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Proteintech
Cardiac Troponin T Monoclonal Antibody (4E2D8), CoraLite® Plus 488
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Product Details
CL488-68300
Product Specifications
Species Reactivity
Chicken,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4E2D8
Immunogen
Cardiac Troponin T fusion protein Ag7716
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSDIEEVVE EYEEEEQEEA AVEEQEEAAE EDAEAEAETE ETRAEEDEEE EEAKEAEDGP MEESKPKPRS FMPNLVPPKI PDGERVDFDD IHRKRMEKDL NELQALIEAH FENRKKEEEE LVSLKDRIER RRAERAEQQR IRNEREKERQ NRLAEERARR EEEENRRKAE DEARKKKALS NMMHFGGYIQ KTERKSGKRQ TEREKKKKIL AERRKVLAID HLNEDQLREK AKELWQSIYN LEAEKFDLQE KFKQQKYEIN VLRNRINDNQ KVSKTRGKAK VTGRWK
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T form I; cardiac troponin T isoform I; cardiac troponin T2; cTnT; MGC3889; TnTC; troponin T; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac
Gene Aliases: cTnT; Ctt; CTTG; RATCTTG; TNNT2; Tnnt3; Tnt
UniProt ID: (Chicken) P02642, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Rabbit) 100009428, (Pig) 100622450, (Chicken) 396433, (Rat) 24837, (Mouse) 21956
muscle contraction
regulation of muscle contraction
sarcomere organization
cardiac muscle contraction
heart development
regulation of heart contraction
metabolic process
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
regulation of muscle filament sliding speed
protein heterooligomerization
response to calcium ion
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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