Search

  • Fale Conosco
  • Pedido rápido

Invitrogen

Parkin Recombinant Rabbit Monoclonal Antibody (21H24L9)

Advanced Verification
View all (38) Parkin antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Parkin Recombinant Rabbit Monoclonal Antibody (21H24L9)

Product Details

740019R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100-1:200
-

Flow Cytometry (Flow)

2 µg/test
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

21H24L9

Immunogen

Protein corresponding to human Parkin (aa1-aa465)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2-7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3074189

Product Specific Information

This is an engineered recombinant antibody that was developed to provide superior sensitivity without changing the paratope. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro.

The advantages of recombinant antibodies include better specificity, lot-to-lot consistency and improved signal-to-noise ratio.

Target Information

The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: E3 ubiquitin ligase; E3 ubiquitin-protein ligase parkin; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; Parkin; parkin 2; Parkin isoform 1; parkin protein; Parkin RBR E3 ubiquitin-protein ligase; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2, E3 ubiquitin protein ligase

View more View less

Gene Aliases: Park; PARK2; PRKN

View more View less

UniProt ID: (Rat) Q9JK66, (Mouse) Q9WVS6

View more View less

Entrez Gene ID: (Rat) 56816, (Mouse) 50873

View more View less

Function(s)
transcription regulatory region sequence-specific DNA binding G-protein coupled receptor binding actin binding ubiquitin-protein transferase activity protein binding zinc ion binding tubulin binding ligase activity kinase binding protein kinase binding PDZ domain binding Hsp70 protein binding heat shock protein binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding protein complex binding identical protein binding histone deacetylase binding ubiquitin binding chaperone binding ubiquitin protein ligase activity cullin family protein binding ubiquitin-specific protease binding F-box domain binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity enzyme binding phospholipase binding coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase
Process(es)
protein polyubiquitination mitochondrial fission mitophagy negative regulation of protein phosphorylation synaptic transmission, dopaminergic startle response transcription, DNA-templated cellular protein modification process ubiquitin-dependent protein catabolic process protein monoubiquitination response to oxidative stress response to unfolded protein mitochondrion organization learning locomotory behavior adult locomotory behavior regulation of autophagy positive regulation of mitochondrial fusion negative regulation of mitochondrial fusion regulation of mitochondrion organization protein ubiquitination protein metabolic process regulation of protein ubiquitination negative regulation of actin filament bundle assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of glucokinase activity response to endoplasmic reticulum stress synaptic transmission, glutamatergic norepinephrine metabolic process dopamine metabolic process response to drug neuron maturation protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding negative regulation of neuron apoptotic process cellular protein catabolic process negative regulation by host of viral genome replication positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of insulin secretion regulation of neurotransmitter secretion modulation of synaptic transmission protein stabilization regulation of protein transport response to corticosterone dopamine uptake involved in synaptic transmission mitochondrion localization protein autoubiquitination zinc ion homeostasis negative regulation of cell death neuron cellular homeostasis protein K63-linked ubiquitination protein localization to mitochondrion aggresome assembly protein K48-linked ubiquitination positive regulation of mitochondrial fission negative regulation of release of cytochrome c from mitochondria cellular response to toxic substance regulation of cellular response to oxidative stress negative regulation of neuron death positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein linear polyubiquitination negative regulation of oxidative stress-induced neuron death positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of transcription, DNA-templated autophagy proteasomal protein catabolic process positive regulation of gene expression negative regulation of gene expression regulation of dopamine metabolic process positive regulation of neurotransmitter uptake regulation of mitochondrial membrane potential protein K11-linked ubiquitination protein K6-linked ubiquitination mitophagy in response to mitochondrial depolarization negative regulation of primary amine oxidase activity regulation of protein targeting to mitochondrion positive regulation of dendrite extension negative regulation of spontaneous neurotransmitter secretion
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support