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Antibodies Inc
Kvbeta1.2 K+ Channel Monoclonal Antibody (K47/42), FL650
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Product Details
75-019-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K47/42
Immunogen
Synthetic peptide amino acids 9-28 of human Kv1.2 (accession number NP_003462).
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ADIPSPKLGL PKSSESALKC
Target Information
KVbeta1.2 is a specific isoform of the beta subunit encoded by the KCNAB1 gene, which is part of the voltage-gated potassium (KV) channel family. These beta subunits modulate the properties and functions of the alpha subunits of KV channels, which are critical for regulating the electrical excitability of cells. KVbeta1.2 is a critical modulator of KV channel function, playing a key role in the regulation of electrical excitability in neurons and cardiac cells. Its proper function is essential for maintaining normal physiological processes, and its dysregulation can lead to significant clinical consequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative splice product of the Shaker beta 1 gene, see GenBank Accession Numbers U16953 and L39833; K(+) channel subunit beta-1; K+ channel Beta1a chain; Kv-beta-1; potassium channel beta 3 chain; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium channel, voltage gated subfamily A regulatory beta subunit 1; potassium voltage gated channel shaker related subfamily beta member 1; potassium voltage gated channel, shaker related subfamily, beta member 1; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; shaker-related subfamily member 1; unnamed protein product; voltage-gated potassium channel beta subunit; Voltage-gated potassium channel subunit beta-1
Gene Aliases: AKR6A3; Akr8a8; hKvb3; hKvBeta3; KCNA1B; KCNAB1; KV-BETA-1; Kvb1; Kvb1.3; Kvbeta1.1; KvBeta3; mKv(beta)1
UniProt ID: (Human) Q14722, (Mouse) P63143, (Rat) P63144
Entrez Gene ID: (Human) 7881, (Mouse) 16497, (Rat) 29737
carbonyl reductase (NADPH) activity
voltage-gated potassium channel activity
protein binding
alcohol dehydrogenase (NADP+) activity
potassium channel regulator activity
oxidoreductase activity
protein domain specific binding
ion channel binding
NADPH binding
molecular function inhibitor activity
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
aldo-keto reductase (NADP) activity
isocitrate dehydrogenase activity
mevaldate reductase activity
voltage-gated ion channel activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
ion transport
potassium ion transport
learning or memory
transmembrane transport
potassium ion transmembrane transport
regulation of potassium ion transmembrane transport
regulation of delayed rectifier potassium channel activity
negative regulation of voltage-gated potassium channel activity
transport
regulation of ion transmembrane transport
oxidation-reduction process
regulation of potassium ion transmembrane transporter activity
negative regulation of delayed rectifier potassium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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