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IP3 Receptor/Type 1 Monoclonal Antibody (L24/18)

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IP3 Receptor/Type 1 Monoclonal Antibody (L24/18)

Product Details

75-035

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

L24/18

Immunogen

Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type 1 IP3R (accession number P29994) produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate-binding protein P400; inositol-1,4,5-triphosphate receptor; inositol-1,4,5-triphosphate receptor (alt., clone pI16); InsP>3

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Gene Aliases: ACV; CLA4; D6Pas2; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R 1; IP3R1; Itpr-1; opt; P400; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29; wblo

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UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994

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Entrez Gene ID: (Human) 3708, (Dog) 476548, (Mouse) 16438, (Rat) 25262

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Function(s)
ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding calcium ion transmembrane transporter activity calcium-release channel activity calcium channel inhibitor activity protein domain specific binding phosphatidylinositol binding protein homodimerization activity inositol 1,4,5 trisphosphate binding inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels ATP binding protein phosphatase binding identical protein binding ion channel binding macromolecular complex binding ligand-gated ion channel
Process(es)
cell morphogenesis response to hypoxia ion transport calcium ion transport signal transduction phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway single fertilization regulation of autophagy calcium-mediated signaling calcium ion transmembrane import into mitochondrion epithelial fluid transport positive regulation of apoptotic process regulation of calcium-mediated signaling negative regulation of calcium-mediated signaling release of sequestered calcium ion into cytosol protein homotetramerization regulation of cytosolic calcium ion concentration transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport regulation of postsynaptic cytosolic calcium ion concentration release of sequestered calcium ion into cytosol by endoplasmic reticulum positive regulation of cytosolic calcium ion concentration post-embryonic development positive regulation of neuron projection development endoplasmic reticulum calcium ion homeostasis negative regulation of apoptotic process voluntary musculoskeletal movement positive regulation of calcium ion transport cellular response to cAMP liver regeneration positive regulation of hepatocyte proliferation dendrite development cellular response to hypoxia
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