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Antibodies Inc
Cavbeta4 Ca2+ Channel Monoclonal Antibody (N10/7), FL490
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Product Details
75-054-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N10/7
Immunogen
Synthetic peptide amino acids 458-474 of rat Cav4 (DENYHNERARKSRNRLS; accession number D4A055).
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAB4; calcium channel beta 4 subunit; Calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; modulates calcium channel function; OTTHUMP00000207247; OTTHUMP00000207249; unnamed protein product; voltage-dependent calcium channel beta 4 subunit; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: 3110038O15Rik; CAB4; CACNB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; lh
UniProt ID: (Human) O00305, (Rat) D4A055, (Mouse) Q8R0S4
Entrez Gene ID: (Pig) 396585, (Human) 785, (Rat) 58942, (Mouse) 12298
voltage-gated calcium channel activity
calcium channel regulator activity
calcium channel activity
protein binding
protein kinase binding
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
high voltage-gated calcium channel activity
voltage-gated ion channel activity
voltage-gated ion channel
ion transport
calcium ion transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuronal action potential propagation
ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
T cell receptor signaling pathway
neurological system process
detection of light stimulus involved in visual perception
muscle cell development
calcium ion transmembrane transport
regulation of presynaptic cytosolic calcium ion concentration
positive regulation of protein localization to nucleolus
cellular response to leukemia inhibitory factor
negative regulation of G1/S transition of mitotic cell cycle
regulation of synaptic vesicle exocytosis
cellular calcium ion homeostasis
T cell differentiation
regulation of ion transmembrane transport
muscle fiber development
synaptic transmission, GABAergic
regulation of voltage-gated calcium channel activity
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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