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Antibodies Inc
FGF12/FHF1 Monoclonal Antibody (N94/17), FL490
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Product Details
75-135-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N94/17
Immunogen
Fusion protein amino acids 1-243 (full-length) of human FGF12a (accession number P61328) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; fibroblast growth factor homologous factor 1b; Myocyte-activating factor; unnamed protein product
Gene Aliases: AV114868; B230343J05Rik; DEE47; EIEE47; FGF-12; FGF12; FGF12B; FHF-1; FHF1; Fhf1b
UniProt ID: (Human) P61328, (Rat) P61150, (Mouse) P61329
Entrez Gene ID: (Human) 2257, (Rat) 170630, (Mouse) 14167
signal transduction
JNK cascade
cell-cell signaling
chemical synaptic transmission
nervous system development
heart development
adult locomotory behavior
fibroblast growth factor receptor signaling pathway
positive regulation of sodium ion transport
neurogenesis
neuromuscular process
cardiac muscle cell action potential involved in contraction
regulation of neuronal action potential
regulation of sodium ion transmembrane transport
regulation of voltage-gated sodium channel activity
regulation of membrane depolarization
regulation of sodium ion transmembrane transporter activity
negative regulation of cation channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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